Integrins are transmembrane proteins that communicate with the ECM to backlink the extracellular setting into the intracellular cytoskeleton.
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The diminished exploratory and social behaviors, and blood hyperserotonemia noticed in KI males are all core phenotypes observed in animal designs of ASD (Silverman et al.
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The context-dependent nature of SERT regulation is underscored from the loss of colocalization of SERT with focal adhesion proteins in KI synapses. This means which the Affiliation of SERT with integrin signaling complexes isn't necessary for the regulation from the transporter by constitutive signaling downstream from the “primed” Pro32Pro33 mutant.
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